Institute of Microbial Technology (सूक्ष्मजीव प्रौद्योगिकी संस्थान)
A Council of Scientific & Industrial Research (वैज्ञानिक औद्योगिक अनुसंधान परिषद)
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Small molecule modulators for selective autophagy from high throughput screening
 
Optineurin (OPTN)
https://pubchem.ncbi.nlm.nih.gov/target/gene/10133#section=BioAssays
https://pubchem.ncbi.nlm.nih.gov/bioassay/624099
https://pubchem.ncbi.nlm.nih.gov/bioassay/651810
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/743121
https://pubchem.ncbi.nlm.nih.gov/bioassay/743454
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117281
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117357
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159506
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159578
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159584
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
NBR1
https://pubchem.ncbi.nlm.nih.gov/target/gene/4077#section=BioAssays
https://pubchem.ncbi.nlm.nih.gov/bioassay/1904
https://pubchem.ncbi.nlm.nih.gov/bioassay/624099
https://pubchem.ncbi.nlm.nih.gov/bioassay/651810
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/743121
https://pubchem.ncbi.nlm.nih.gov/bioassay/743454
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117281
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117357
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159506
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159578
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159584
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
FUNDC1
https://pubchem.ncbi.nlm.nih.gov/target/gene/139341#section=Top
https://pubchem.ncbi.nlm.nih.gov/bioassay/1904
https://pubchem.ncbi.nlm.nih.gov/bioassay/624099
https://pubchem.ncbi.nlm.nih.gov/bioassay/651810
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/743454
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117281
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117357
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159506
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159578
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159584
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
BNIP3
https://pubchem.ncbi.nlm.nih.gov/target/gene/664#section=BioAssays
https://pubchem.ncbi.nlm.nih.gov/bioassay/1904
https://pubchem.ncbi.nlm.nih.gov/bioassay/624099
https://pubchem.ncbi.nlm.nih.gov/bioassay/651810
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/720710
https://pubchem.ncbi.nlm.nih.gov/bioassay/743121
https://pubchem.ncbi.nlm.nih.gov/bioassay/743454
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117281
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117357
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159506
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159578
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159584
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
VCP
https://pubchem.ncbi.nlm.nih.gov/bioassay/1544
https://pubchem.ncbi.nlm.nih.gov/bioassay/1794
https://pubchem.ncbi.nlm.nih.gov/bioassay/504653
https://pubchem.ncbi.nlm.nih.gov/bioassay/1534
https://pubchem.ncbi.nlm.nih.gov/bioassay/1517
https://pubchem.ncbi.nlm.nih.gov/bioassay/504654
https://pubchem.ncbi.nlm.nih.gov/bioassay/488830
https://pubchem.ncbi.nlm.nih.gov/bioassay/463184
https://pubchem.ncbi.nlm.nih.gov/bioassay/504649
https://pubchem.ncbi.nlm.nih.gov/bioassay/2131
https://pubchem.ncbi.nlm.nih.gov/bioassay/1481
https://pubchem.ncbi.nlm.nih.gov/bioassay/1551
https://pubchem.ncbi.nlm.nih.gov/bioassay/463185
https://pubchem.ncbi.nlm.nih.gov/bioassay/504650
https://pubchem.ncbi.nlm.nih.gov/bioassay/488828
https://pubchem.ncbi.nlm.nih.gov/bioassay/465028
https://pubchem.ncbi.nlm.nih.gov/bioassay/465027
https://pubchem.ncbi.nlm.nih.gov/bioassay/465026
https://pubchem.ncbi.nlm.nih.gov/bioassay/1258962
https://pubchem.ncbi.nlm.nih.gov/bioassay/465024
https://pubchem.ncbi.nlm.nih.gov/bioassay/977611
https://pubchem.ncbi.nlm.nih.gov/bioassay/465029
https://pubchem.ncbi.nlm.nih.gov/bioassay/1175534
https://pubchem.ncbi.nlm.nih.gov/bioassay/721966
https://pubchem.ncbi.nlm.nih.gov/bioassay/721967
https://pubchem.ncbi.nlm.nih.gov/bioassay/721949
https://pubchem.ncbi.nlm.nih.gov/bioassay/721948
https://pubchem.ncbi.nlm.nih.gov/bioassay/721947
https://pubchem.ncbi.nlm.nih.gov/bioassay/721946
https://pubchem.ncbi.nlm.nih.gov/bioassay/721945
https://pubchem.ncbi.nlm.nih.gov/bioassay/1175535
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224831
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
https://pubchem.ncbi.nlm.nih.gov/bioassay/769518
https://pubchem.ncbi.nlm.nih.gov/bioassay/624887
https://pubchem.ncbi.nlm.nih.gov/bioassay/435289
PRKN
https://pubchem.ncbi.nlm.nih.gov/bioassay/720555
https://pubchem.ncbi.nlm.nih.gov/bioassay/720549
https://pubchem.ncbi.nlm.nih.gov/bioassay/720573
https://pubchem.ncbi.nlm.nih.gov/bioassay/720572
https://pubchem.ncbi.nlm.nih.gov/bioassay/720571
https://pubchem.ncbi.nlm.nih.gov/bioassay/624263
FYCO1
https://pubchem.ncbi.nlm.nih.gov/target/gene/79443#section=BioAssays
https://pubchem.ncbi.nlm.nih.gov/bioassay/1904
https://pubchem.ncbi.nlm.nih.gov/bioassay/624099
https://pubchem.ncbi.nlm.nih.gov/bioassay/651810
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/743454
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117281
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117357
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159506
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159578
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159584
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
SNX18
https://pubchem.ncbi.nlm.nih.gov/bioassay/1904
https://pubchem.ncbi.nlm.nih.gov/bioassay/624099
https://pubchem.ncbi.nlm.nih.gov/bioassay/651810
https://pubchem.ncbi.nlm.nih.gov/bioassay/651811
https://pubchem.ncbi.nlm.nih.gov/bioassay/743454
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117281
https://pubchem.ncbi.nlm.nih.gov/bioassay/1117357
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159506
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159578
https://pubchem.ncbi.nlm.nih.gov/bioassay/1159584
https://pubchem.ncbi.nlm.nih.gov/bioassay/1224830
SQSTM
The SQSTM protein also known as sequestosome-1 recognizes specific cargos such as toxic cellular waste, which then get sequestered in an autophagosome. Lack of autophagy leads to accrual of SQSTM, which is not healthy as it leads to cellular stress induced disease. Targeting SQSTM with small molecule modulators which can cause its decreased accumulation would be helpful. Indirect evidences are there for various molecules which affect the levels of SQSTM, like BRD5631 increases the SQSTM levels along with LC3II in Atg5+/+ mouse embryonic fibroblasts. On the contrary, treatment with BRD5631, BRD2716, and BRD34009 reduced levels of endogenous SQSTM in NPC1 neuronal cells suggesting complex effect of BRD series of compounds on SQSTM levels in the cellular context. Another compound clenbuterol leads to decreased levels of SQSTM in HepG2 cells and primary mouse hepatocytes. Hydroxychloroquine (HCQ) and chloroquine analog EAD1 also accumulate the SQSTM protein in lung and pancreatic cancer cell lines. Collectively all these compounds indirectly modulate the SQSTM levels in varied cell types thus can be utilized for targeting autophagy in a non-specific manner.
https://www.ncbi.nlm.nih.gov/pubmed/24950230
https://www.ncbi.nlm.nih.gov/pubmed/25699157
https://www.ncbi.nlm.nih.gov/pubmed/26195741
https://www.ncbi.nlm.nih.gov/pcassay?term=autophagy
https://www.ncbi.nlm.nih.gov/pcassay?db=pcassay&cmd=search&term=autophagy AND (pcassay_pccompound_active[filt])&loc=s_frm
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