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Target name PDB ID Structure title Experimental Method Resolution PMID
MTOR 4JSV mTOR kinase structure, mechanism and regulation X-RAY DIFFRACTION 3.5 Å 23636326
PI3K 4YKN Pi3K alpha lipid kinase with Active Site Inhibitor X-RAY DIFFRACTION 2.9 Å 26005528
PI3K 4XZ4 Structure of PI3K gamma in complex with an inhibitor X-RAY DIFFRACTION 2.6 Å To Be Published
PRKA 4REW Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex X-RAY DIFFRACTION 4.58 Å 25412657
PRKA 4CFE Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative X-RAY DIFFRACTION 3.02 Å 24352254
PRKA 5EZV Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding X-RAY DIFFRACTION 2.99 Å 26952388
EIF2 1Q8K Solution Structure of Human Initiation Factor eIF2alpha Reveals Homology to the Elongation Factor eEF1B SOLUTION NMR   15341733
MAPK14 1BL6 THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995 X-RAY DIFFRACTION 2.5 Å 9753691
MAPK14 1W84 P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH SMALL MOLECULE INHIBITOR X-RAY DIFFRACTION 2.2 Å 15658855
MAPK8 3O17 Crystal Structure of JNK1-alpha1 isoform X-RAY DIFFRACTION 3.0 Å To Be Published
MAPK8 4H39 Crystal Structure of JNK3 in Complex with JIP1 Peptide X-RAY DIFFRACTION 1.99 Å 23142346
MAPK8 3PTG Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor X-RAY DIFFRACTION 2.43 Å 21316234
MAPK1 4QP2 Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine X-RAY DIFFRACTION 2.23 Å 26338362
MAPK1 4ZZM Human ERK2 in complex with an irreversible inhibitor X-RAY DIFFRACTION 1.89 Å 25977981
MAPK1 3I60 Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide X-RAY DIFFRACTION 2.5 Å 19827834
MAPK1 1TVO The structure of ERK2 in complex with a small molecule inhibitor X-RAY DIFFRACTION 2.5 Å 16139248
BCL2 2XA0 CRYSTAL STRUCTURE OF BCL-2 IN COMPLEX WITH A BAX BH3 PEPTIDE X-RAY DIFFRACTION 2.7 Å 21060336
BCL2 4AQ3 HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR X-RAY DIFFRACTION 2.4 Å 22608961
BCL2 4LXD Bcl_2-Navitoclax Analog (without Thiophenyl) Complex X-RAY DIFFRACTION 1.9 Å 23291630
BCL2 4LVT Bcl_2-Navitoclax (ABT-263) Complex X-RAY DIFFRACTION 2.05 Å 23291630
ROCK 4YVC ROCK 1 bound to thiazole inhibitor X-RAY DIFFRACTION 3.2 Å 26039570
ROCK 4YVE ROCK 1 bound to methoxyphenyl thiazole inhibitor X-RAY DIFFRACTION 3.4 Å 26039570
ROCK 4W7P Crystal Structure of ROCK 1 bound to YB-15-QD37 X-RAY DIFFRACTION 2.8 Å 25248678
ROCK 3TWJ Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447 X-RAY DIFFRACTION 2.9 Å 22846914
EGFR 4ZAU AZD9291 complex with wild type EGFR X-RAY DIFFRACTION 2.8 Å 26522274
EGFR 2N5S Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles SOLUTION NMR   26440883
EGFR 4RJ5 EGFR kinase (T790M/L858R) with inhibitor compound 5 X-RAY DIFFRACTION 3.1 Å 25383627
YWHAQ 4DHM Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening X-RAY DIFFRACTION1.7 Å 1.7 Å 23939230
TP53 4HJE Crystal structure of p53 core domain in complex with DNA X-RAY DIFFRACTION 1.91 Å 23836939
TP53 3IGK Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2) X-RAY DIFFRACTION 1.7 Å 20364130
VDR 1S19 Crystal structure of VDR ligand binding domain complexed to calcipotriol X-RAY DIFFRACTION 2.1 Å 15055995
VDR 3A78 Crystal structure of the human VDR ligand binding domain bound to the natural metabolite 1alpha,25-dihydroxy-3-epi-vitamin D3 X-RAY DIFFRACTION 1.9 Å To Be Published
VDR 3A40 Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277B(C23R) X-RAY DIFFRACTION 1.45 Å 20070104
VDR 2HAM Crystal structure of VDR LBD complexed to 2alpha-propyl-calcitriol X-RAY DIFFRACTION 1.9 Å 16913708
PPARG 2Q59 Crystal Structure of PPARgamma LBD bound to full agonist MRL20 X-RAY DIFFRACTION 2.2 Å 17937915
PPARG 4R06 Crystal Structure of SR2067 bound to PPARgamma X-RAY DIFFRACTION 2.22 Å 26579553
RAR 1DKF CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS X-RAY DIFFRACTION 2.5 Å 10882070
RAR 3KMZ Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment X-RAY DIFFRACTION 2.1 Å 20543827
RAR 1XAP Structure of the ligand binding domain of the Retinoic Acid Receptor beta X-RAY DIFFRACTION 2.1 Å 15319780
RAR 3LBD LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID X-RAY DIFFRACTION 2.4 Å 9501913
RAR 4LBD LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961 X-RAY DIFFRACTION 2.5 Å 9501913
GR 4UDC GR in complex with dexamethasone X-RAY DIFFRACTION 2.5 Å 26602186
GR 4UDD GR in complex with desisobutyrylciclesonide X-RAY DIFFRACTION 1.8 Å 26602186
GR 3H52 Crystal structure of the antagonist form of human glucocorticoid receptor X-RAY DIFFRACTION 2.8 Å 19913032
GR 3E7C Glucocorticoid Receptor LBD bound to GSK866 X-RAY DIFFRACTION 2.15 Å 18952422
GR 5CJ6 Crystal Structure of a Selective Androgen Receptor Modulator Bound to the Ligand Binding Domain of the Human Androgen Receptor X-RAY DIFFRACTION 2.07 Å 26683992
AR 4QL8 Crystal structure of Androgen Receptor in complex with the ligand X-RAY DIFFRACTION 2.1 Å 25121964
AR 4OEA Crystal structure of AR-LBD X-RAY DIFFRACTION 2.12 Å 25091737
NR4A1 2QW4 Human NR4A1 ligand-binding domain X-RAY DIFFRACTION 2.8 Å To Be Published
NR4A1 3V3E Crystal Structure of the Human Nur77 Ligand-binding Domain X-RAY DIFFRACTION 2.06 Å 22983157
NR4A1 4JGV Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN X-RAY DIFFRACTION 3.01 Å 24316735
NR4A1 4RZG Crystal Structure Analysis of the DNPA-bounded NUR77 Ligand binding Domain X-RAY DIFFRACTION 2.7 Å 25822914
CEBPB 1GU4 CRYSTAL STRUCTURE OF C/EBPBETA BZIP DIMERIC BOUND TO A HIGH AFFINITY DNA FRAGMENT X-RAY DIFFRACTION 1.8 Å To Be Published
FOXO3 2UZK Crystal structure of the human FOXO3a-DBD bound to DNA X-RAY DIFFRACTION 2.7 Å 17940099
HIF1 4EQ1 Crystal Structure of the ARNT PAS-B homodimer X-RAY DIFFRACTION 1.6 Å 23240775
HIF2 4GS9 Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist X-RAY DIFFRACTION 1.72 Å 23363003
SREBF2 1UKL Crystal structure of Importin-beta and SREBP-2 complex X-RAY DIFFRACTION 3.0 Å 14645851
ULK1 4WNO Structure of ULK1 bound to an inhibitor X-RAY DIFFRACTION 1.56 Å 25551253
ULK1 4WNP Structure of ULK1 bound to a potent inhibitor X-RAY DIFFRACTION 1.88 Å 25551253
ATG13 3WAN Crystal structure of Atg13 LIR-fused human LC3A_2-121 X-RAY DIFFRACTION 1.77 Å To Be Published
ATG13 5C50 Crystal structure of the complex of human Atg101-Atg13 HORMA domain X-RAY DIFFRACTION 1.63 Å 26299944
BECN1 4DDP crystal structure of Beclin 1 evolutionarily conserved domain(ECD) X-RAY DIFFRACTION 1.55Å 22310240
BECN1 2P1L Structure of the Bcl-XL:Beclin 1 complex X-RAY DIFFRACTION 2.5Å 17337444
PIK3C3 4PH4 The crystal structure of Human VPS34 in complex with PIK-III X-RAY DIFFRACTION 2.8 Å 25327288
PIK3C3 4OYS CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405 X-RAY DIFFRACTION 2.9 Å 25326666
ATG12 4GDK Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1 X-RAY DIFFRACTION 2.7 Å 23202584
ATG12 4GDL Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1 X-RAY DIFFRACTION 2.88 Å 23202584
ATG5 5D7G Structure of human ATG5 E122D-ATG16L1 complex at 3.0 Angstroms X-RAY DIFFRACTION 3.0 Å 26812546
ATG3 3WIM GABARAP-LIR peptide complex X-RAY DIFFRACTION 2.6 Å To Be Published
ATG3 4NAW Crystal Structure of Human ATG12~ATG5-ATG16N in complex with a fragment of ATG3 X-RAY DIFFRACTION 2.19 Å 24191030
ATG4 2D1I Structure of human Atg4b X-RAY DIFFRACTION 2.0 Å 16325851
ATG4 2CY7 The crystal structure of human Atg4B X-RAY DIFFRACTION 1.9 Å 16183633
NFKB 1NFI I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX X-RAY DIFFRACTION 2.7 Å 9865693
NFKB 3QXY Human SETD6 in complex with RelA Lys310 X-RAY DIFFRACTION 2.09 Å 21515635
NFKB 3RC0 Human SETD6 in complex with RelA Lys310 peptide X-RAY DIFFRACTION 2.19 Å 21515635
NFKB 1SVC NFKB P50 HOMODIMER BOUND TO DNA X-RAY DIFFRACTION 2.6 Å 7830764
PTPN22 2P6X Crystal structure of human tyrosine phosphatase PTPN22 X-RAY DIFFRACTION 1.9 Å 19167335
PTPN22 3OMH Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide X-RAY DIFFRACTION 2.9 Å 21719704
NLRP3 3QF2 Crystal structure of NALP3 PYD X-RAY DIFFRACTION 1.7 Å 21880711
NLRX1 3UN9 Crystal structure of an immune receptor X-RAY DIFFRACTION 2.65 Å 22386589
NLRP4 4EWI Crystal structure of the NLRP4 Pyrin domain X-RAY DIFFRACTION 2.28 Å 22928810
AP-1 1JNM Crystal Structure of the Jun/CRE Complex X-RAY DIFFRACTION 2.2 Å To Be Published
AP-1 1S9K Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site X-RAY DIFFRACTION 3.1 Å To Be Published
AP-1 1t2k Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA X-RAY DIFFRACTION 3.0 Å 15510218
AP-1 1FOS TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES X-RAY DIFFRACTION 3.05 Å 7816143
TP63 3zy1 Crystal structure of the human p63 tetramerization domain X-RAY DIFFRACTION 2.15Å 22100306
TP63 4a9z CRYSTAL STRUCTURE OF HUMAN P63 TETRAMERIZATION DOMAIN X-RAY DIFFRACTION 2.29Å To Be Published
TP73 2wqi CRYSTAL STRUCTURE OF THE HUMAN P73 TETRAMERIZATION DOMAIN X-RAY DIFFRACTION 1.7Å 19815500
TP73 2wqj CRYSTAL STRUCTURE OF A TRUNCATED VARIANT OF THE HUMAN P73 TETRAMERIZATION DOMAIN X-RAY DIFFRACTION 19815500
STAT1 1yvl Structure of Unphosphorylated STAT1 X-RAY DIFFRACTION 15780933
STAT1 3wwt Crystal Structure of the Y3:STAT1ND complex X-RAY DIFFRACTION To Be Published
NR1H4 4wvd Identification of a novel FXR ligand that regulates metabolism X-RAY DIFFRACTION 2.5 Å 23728580
NR1H4 3dct Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. X-RAY DIFFRACTION 2.5 Å 18621523
PPARA 2znn Human PPAR alpha ligand binding domain in complex with a synthetic agonist TIPP703 X-RAY DIFFRACTION 2.01 Å 19622862
HDAC6 3c5k Crystal structure of human HDAC6 zinc finger domain X-RAY DIFFRACTION 1.55 Å To Be Published
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