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PDB ID Structure Title Exp. Method Resolution Structure MW Residue Count Title PubMed ID
1BY4 STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA X-RAY DIFFRACTION 2.10 58062.50 390 Structural basis of RXR-DNA interactions. 10669605
1DSZ STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 X-RAY DIFFRACTION 1.70 29654.19 201 Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1. 10698945
1G1U THE 2.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN IN TETRAMER IN THE ABSENCE OF LIGAND X-RAY DIFFRACTION 2.50 106672.00 952 Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix. 10970886
1HLZ CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT X-RAY DIFFRACTION 2.80 34333.78 228 DNA Deformability as a Recognition Feature in the RevErb Response Element 11669620
1ILG Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain X-RAY DIFFRACTION 2.52 36281.20 316 The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. 11408620
1KV6 X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation X-RAY DIFFRACTION 2.70 55721.38 490 Structural and Functional Evidence for Ligand-Independent Transcriptional Activation by the Estrogen-Related Receptor 3 11864604
1LBD LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA X-RAY DIFFRACTION 2.70 31702.50 282 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. 7760929
1LO1 ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA SOLUTION NMR   19223.21 124 Monomeric Complex of Human Orphan Estrogen Related Receptor-2 with DNA: A Pseudo-dimer Interface Mediates Extended Half-site Recognition 12654265
1PRG LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA X-RAY DIFFRACTION 2.20 61668.20 540 Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. 9744270
1R0N Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex X-RAY DIFFRACTION 2.60 33186.63 226 Structure of the heterodimeric Ecdysone Receptor DNA-binding complex 14592980
1RXR HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE SOLUTION NMR   9948.19 83 High-resolution solution structure of the retinoid X receptor DNA-binding domain. 9698548
1TFC CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH A STEROID RECEPTOR COACTIVATOR-1 PEPTIDE X-RAY DIFFRACTION 2.40 60326.38 532 Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity. 15161930
1XB7 X-ray structure of ERRalpha LBD in complex with a PGC-1alpha peptide at 2.5A resolution X-RAY DIFFRACTION 2.50 28553.95 259 Evidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor {alpha} (ERR{alpha}): CRYSTAL STRUCTURE OF ERR{alpha} LIGAND BINDING DOMAIN IN COMPLEX WITH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR COACTIVATOR-1{alpha} 15337744
1YNW Crystal Structure of Vitamin D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element X-RAY DIFFRACTION 3.00 35710.27 245 Structural analysis of RXR-VDR interactions on DR3 DNA 15225774
2EBL Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1 SOLUTION NMR   10031.11 89 Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1
2ENV Solution sturcture of the C4-type zinc finger domain from human Peroxisome proliferator-activated receptor delta SOLUTION NMR   9933.16 88 Solution sturcture of the C4-type zinc finger domain from human Peroxisome proliferator-activated receptor delta
2GL8 Human Retinoic acid receptor RXR-gamma ligand-binding domain X-RAY DIFFRACTION 2.40 107984.80 964 The Crystal Structure of Human Retinoic acid receptor RXR-gamma ligand-binding domain.
2GP7 Estrogen Related Receptor-gamma ligand binding domain X-RAY DIFFRACTION 2.45 104378.48 920 X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. 16990259
2GPO Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140 X-RAY DIFFRACTION 1.95 28917.92 255 X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. 16990259
2GWX MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS X-RAY DIFFRACTION 2.30 61137.60 534 Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. 10198642
2QMV High Resolution Structure of Peroxisone Proliferation-Activated Receptor gamma and Characterisation of its Interaction with the Co-activator Transcriptional Intermediary Factor 2 SOLUTION NMR   30834.10 270 High Resolution Structure of Peroxisone Proliferation-Activated Receptor gamma and Characterisation of its Interaction with the Co-activator Transcriptional Intermediary Factor 2
2QW4 Human NR4A1 ligand-binding domain X-RAY DIFFRACTION 2.80 121081.20 1092 Crystal Structure of Human Nr4A1 Ligand-Binding Domain
2V0V CRYSTAL STRUCTURE OF REV-ERB BETA X-RAY DIFFRACTION 2.40 87777.20 776 Structural Insight Into the Constitutive Repression Function of the Nuclear Receptor Rev-Erbbeta 17870090
2ZBS Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form X-RAY DIFFRACTION 1.80 27611.30 244 ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner 18582436
2ZK0 Human peroxisome proliferator-activated receptor gamma ligand binding domain X-RAY DIFFRACTION 2.36 65061.80 572 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids 18977231
3CBB Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product X-RAY DIFFRACTION 2.00 31260.20 198 Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product. 18829458
3CJW Crystal structure of the human COUP-TFII ligand binding domain X-RAY DIFFRACTION 1.48 27311.70 244 Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid-Activated Receptor. 18798693
3CTB Tethered PXR-LBD/SRC-1p apoprotein X-RAY DIFFRACTION 2.00 78368.80 688 Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability 18456871
3D24 Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha) X-RAY DIFFRACTION 2.11 60502.20 550 Communication between the ERR{alpha} Homodimer Interface and the PGC-1{alpha} Binding Surface via the Helix 8-9 Loop. 18441008
3N00 Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A X-RAY DIFFRACTION 2.60 30082.58 266 Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction. 20581824
3NSP Crystal structure of tetrameric RXRalpha-LBD X-RAY DIFFRACTION 2.90 53712.40 480 Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. 21084305
3P0U Crystal Structure of the ligand binding domain of human testicular receptor 4 X-RAY DIFFRACTION 3.00 56204.80 498 The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor. 21068381
3PRG LIGAND BINDING DOMAIN OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR X-RAY DIFFRACTION 2.90 31793.20 278 Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma. 9813012
3R29 Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 X-RAY DIFFRACTION 2.90 57210.76 512 Structural basis for retinoic x receptor repression on the tetramer. 21613212
4B7W Ligand binding domain human hepatocyte nuclear factor 4alpha: Apo form X-RAY DIFFRACTION 4.00 107685.60 956 Fatty Acids are not Essential Structural Components of Hepatocyte Nuclear Factor 4Alpha
4IS8 Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors X-RAY DIFFRACTION 2.78 55690.60 478 Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors. 23737522
4J5W Crystal Structure of the apo-PXR/RXRalpha LBD Heterotetramer Complex X-RAY DIFFRACTION 2.80 135123.02 1200 Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. 23602807
4PRG 0072 PARTIAL AGONIST PPAR GAMMA COCRYSTAL X-RAY DIFFRACTION 2.90 125795.76 1080 A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. 10339548
4NIE Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand X-RAY DIFFRACTION 2.01 65684.93 548 Discovery of Tertiary Amine and Indole Derivatives as Potent ROR-gamma-t Inverse Agonists
4NB6 Crystal structure of the ligand binding domain of RORC with T0901317 X-RAY DIFFRACTION 2.85 59046.06 502 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. 24239186
4M8H CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (R)4-METHYL 9cUAB30 AND COACTIVATOR PEPTIDE GRIP-1 X-RAY DIFFRACTION 2.20 27613.35 242 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. 24359708
4M8E CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (S) 4-Methyl 9cUAB30 COACTIVATOR PEPTIDE GRIP-1 X-RAY DIFFRACTION 2.40 27613.35 242 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. 24359708
4KZM Crystal Structure of TR3 LBD S553A Mutant X-RAY DIFFRACTION 2.30 57735.28 514 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
4KZJ Crystal Structure of TR3 LBD L449W Mutant X-RAY DIFFRACTION 2.12 57913.48 514 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
4KZI Crystal Structure of TR3 LBD in complex with DPDO X-RAY DIFFRACTION 2.41 58059.70 514 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
4K6I Crystal structure of human retinoid X receptor alpha-ligand binding domain complex with Targretin and the coactivator peptide GRIP-1 X-RAY DIFFRACTION 2.10 27825.56 244 Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain. 24187139
4K4J Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9cUAB30 and the coactivator peptide GRIP-1 X-RAY DIFFRACTION 2.00 27771.47 244 Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain. 24187139
4JGV Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN X-RAY DIFFRACTION 3.01 56171.39 498 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
4J5X Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex X-RAY DIFFRACTION 2.80 136083.48 1200 Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. 23602807
4IQR Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA X-RAY DIFFRACTION 2.90 186731.91 1484 Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. 23485969
4II6 Identification of a novel FXR ligand that regulates metabolism X-RAY DIFFRACTION 2.90 56307.02 466 The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism 23728580
4HEE Crystal structure of PPARgamma in complex with compound 13 X-RAY DIFFRACTION 2.50 35649.58 307 Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-gamma 23265881
4FGY Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity X-RAY DIFFRACTION 2.84 32990.88 281 Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. 23178929
4F9M Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator X-RAY DIFFRACTION 1.90 34720.53 298 Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators 22727448
4EMA Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone X-RAY DIFFRACTION 2.55 63178.82 550 Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists 22649490
4EM9 Human PPAR gamma in complex with nonanoic acids X-RAY DIFFRACTION 2.10 63980.83 550 Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists 22649490
4E4Q Crystal structure of PPARgamma with the ligand FS214 X-RAY DIFFRACTION 2.50 65748.65 574 New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression. 23171045
4E4K Crystal Structure of PPARgamma with the ligand JO21 X-RAY DIFFRACTION 2.50 66109.10 574 New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression. 23171045
4DOS Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to DLPC and a Fragment of TIF-2 X-RAY DIFFRACTION 2.00 32669.98 270 Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. 22504882
4DOR Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, in its apo State Bound to a Fragment of Human SHP Box1 X-RAY DIFFRACTION 1.90 62529.52 538 Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. 22504882
4DK8 Crystal structure of LXR ligand binding domain in complex with partial agonist 5 X-RAY DIFFRACTION 2.75 61358.00 518 Discovery of a new binding mode for a series of liver X receptor agonists. 22406115
4DK7 Crystal structure of LXR ligand binding domain in complex with full agonist 1 X-RAY DIFFRACTION 2.45 61850.57 518 Discovery of a new binding mode for a series of liver X receptor agonists. 22406115
4BCR Structure of PPARalpha in complex with WY14643 X-RAY DIFFRACTION 2.50 63451.93 548 Molecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization 23707408
4A4W Ligand binding domain of human PPAR gamma in complex with amorfrutin B X-RAY DIFFRACTION 2.00 66205.27 574 Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor Gamma. 23286787
4A4V Ligand binding domain of human PPAR gamma in complex with amorfrutin 2 X-RAY DIFFRACTION 2.00 66001.00 574 Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor Gamma. 23286787
3VSP Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28 X-RAY DIFFRACTION 2.40 65576.46 572 Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28
3VSO Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21 X-RAY DIFFRACTION 2.00 65571.40 572 Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility 23490155
3VN2 Crystal Structure of PPARgamma complexed with Telmisartan X-RAY DIFFRACTION 2.18 34913.73 301 Structural basis for telmisartan-mediated partial activation of PPAR gamma 22357520
3VJI Human PPAR gamma ligand binding domain in complex with JKPL53 X-RAY DIFFRACTION 2.61 65579.51 572 Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype. 22185225
3VJH Human PPAR GAMMA ligand binding domain in complex with JKPL35 X-RAY DIFFRACTION 2.22 65485.23 572 Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype. 22185225
3VI8 Human PPRR alpha ligand binding domain in complex with a synthetic agonist APHM13 X-RAY DIFFRACTION 1.75 31321.85 273 Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype 22185225
3V9Y Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator X-RAY DIFFRACTION 2.10 34760.57 298 Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR(gamma) partial agonists 22225641
3V9V Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator X-RAY DIFFRACTION 1.60 35051.88 302 Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR(gamma) partial agonists 22225641
3V9T Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator X-RAY DIFFRACTION 1.65 35009.85 302 Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR(gamma) partial agonists 22225641
3V3Q Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate X-RAY DIFFRACTION 2.22 58643.33 514 The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK 22983157
3V3E Crystal Structure of the Human Nur77 Ligand-binding Domain X-RAY DIFFRACTION 2.06 57767.28 514 The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK 22983157
3UVV Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid X-RAY DIFFRACTION 2.95 58389.32 509 Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers. 22474364
3U9Q Ligand binding domain of PPARgamma complexed with Decanoic Acid and PGC-1a peptide X-RAY DIFFRACTION 1.52 31877.60 278 Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors. 22039047
3TY0 Structure of PPARgamma ligand binding domain in complex with (R)-5-(3-((3-(6-methoxybenzo[d]isoxazol-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-5-methyloxazolidine-2,4-dione X-RAY DIFFRACTION 2.00 64156.73 554 Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) modulators. 22070604
3TX7 Crystal structure of LRH-1/beta-catenin complex X-RAY DIFFRACTION 2.76 98273.30 879 Structural basis of coactivation of liver receptor homolog-1 by beta-catenin. 22187462
3TKM Crystal structure PPAR delta binding GW0742 X-RAY DIFFRACTION 1.95 31994.38 275 Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding. 22606221
3T03 Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16 X-RAY DIFFRACTION 2.10 69875.15 604 GQ-16, a novel peroxisome proliferator-activated receptor (PPAR gamma) ligand, promotes insulin sensitization without weight gain. 22584573
3SZ1 Human PPAR gamma ligand binding domain in complex with luteolin and myristic acid X-RAY DIFFRACTION 2.30 64301.29 556 Mode of peroxisome proliferator-activated receptor gamma activation by luteolin. 22391103
3SP9 Structural basis for iloprost as a dual PPARalpha/delta agonist X-RAY DIFFRACTION 2.30 65180.38 562 Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist. 21775429
3SP6 Structural basis for iloprost as a dual PPARalpha/delta agonist X-RAY DIFFRACTION 2.21 33916.83 296 Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist. 21775429
3S9S Ligand binding domain of PPARgamma complexed with a benzimidazole partial agonist X-RAY DIFFRACTION 2.55 34670.41 297 Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARgamma partial agonist. 21798739
3RVF FXR with SRC1 and GSK2034 X-RAY DIFFRACTION 3.10 30315.70 253 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. 21890356
3RUU FXR with SRC1 and GSK237 X-RAY DIFFRACTION 2.50 28933.18 240 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. 21890356
3RUT FXR with SRC1 and GSK359 X-RAY DIFFRACTION 3.00 28950.22 240 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. 21890356
3R8I Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86) X-RAY DIFFRACTION 2.30 65826.77 574 Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 22081932
3R8D Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721 X-RAY DIFFRACTION 2.80 36587.97 316 Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. 21805522
3R8A X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity X-RAY DIFFRACTION 2.41 65530.66 564 Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-gamma. 21557540
3R5N Crystal structure of PPARgammaLBD complexed with the agonist magnolol X-RAY DIFFRACTION 2.00 31854.38 274 Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). 22140563
3R5M Crystal structure of RXRalphaLBD complexed with the agonist magnolol X-RAY DIFFRACTION 2.80 56798.16 500 Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). 22140563
3R2A Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein X-RAY DIFFRACTION 3.00 111491.61 992 Structural basis for retinoic x receptor repression on the tetramer. 21613212
3QT0 Revealing a steroid receptor ligand as a unique PPARgamma agonist X-RAY DIFFRACTION 2.50 33332.10 287 Revealing a steroid receptor ligand as a unique PPAR gamma agonist. 21986665
3PLZ Human LRH1 LBD bound to GR470 X-RAY DIFFRACTION 1.75 64028.82 542 Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2). 21391689
3PEQ PPARd complexed with a phenoxyacetic acid partial agonist X-RAY DIFFRACTION 2.40 64688.38 542 Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy 21414782
3PCU Crystal structure of human retinoic X receptor alpha ligand-binding domain complexed with LX0278 and SRC1 peptide X-RAY DIFFRACTION 2.00 27401.06 240 (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice. 22384078
3PBA Crystal structure of PPARgamma ligand binding domain in complex with monosulfate tetrabromo-bisphenol A (MonoTBBPA) X-RAY DIFFRACTION 2.30 65946.03 572 Characterization of Novel Ligands of ER{alpha}, Er{beta}, and PPAR{gamma}: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites. 21622942
3P89 FXR bound to a quinolinecarboxylic acid X-RAY DIFFRACTION 2.30 28901.03 240 Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene. 21256005
3P88 FXR bound to isoquinolinecarboxylic acid X-RAY DIFFRACTION 2.95 28876.19 240 Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene. 21256005
3OZJ Crystal structure of human retinoic X receptor alpha complexed with bigelovin and coactivator SRC-1 X-RAY DIFFRACTION 2.10 56756.12 498 Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode 21262235
3OZ0 PPAR Delta in complex with azppard02 X-RAY DIFFRACTION 3.00 33166.47 285 Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists 21094606
3OSW Crystal structure of PPARgamma ligand binding domain in complex with tetrabromo-bisphenol A (TBBPA) X-RAY DIFFRACTION 2.55 65539.57 570 Peroxisome proliferator-activated receptor Gamma is a target for halogenated analogs of bisphenol A. 21561829
3OSI Crystal structure of PPARgamma ligand binding domain in complex with tetrachloro-bisphenol A (TCBPA) X-RAY DIFFRACTION 2.70 65361.77 570 Peroxisome proliferator-activated receptor Gamma is a target for halogenated analogs of bisphenol A. 21561829
3OOK Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid X-RAY DIFFRACTION 2.29 58900.77 494 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
3OOF Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)benzoic acid X-RAY DIFFRACTION 2.29 58828.81 494 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
3OMM Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid X-RAY DIFFRACTION 2.10 58864.79 494 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
3OMK Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide X-RAY DIFFRACTION 1.90 58768.85 494 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
3OLF Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid X-RAY DIFFRACTION 1.90 58856.87 494 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
3OKI Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide X-RAY DIFFRACTION 2.00 58680.92 494 Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes 21134747
3OKH Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid X-RAY DIFFRACTION 2.50 29878.50 247 Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes 21134747
3OAP Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9-cis retinoic acid and the coactivator peptide GRIP-1 X-RAY DIFFRACTION 2.05 27603.36 242 Structure, Energetics and Dynamics of Binding Coactivator Peptide to Human Retinoid X Receptor Alpha Ligand Binding Domain Complex with 9-cis-Retinoic Acid. 21049972
3NSQ Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron X-RAY DIFFRACTION 2.60 53952.61 480 Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. 21084305
3NOA Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist X-RAY DIFFRACTION 1.98 63089.90 542 Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist
3LMP Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator X-RAY DIFFRACTION 1.90 34674.48 298 Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives 20219371
3L1B Complex Structure of FXR Ligand-binding domain with a tetrahydroazepinoindole compound X-RAY DIFFRACTION 1.90 27705.97 233 Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates. 20095622
3L0L Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand X-RAY DIFFRACTION 1.74 61780.36 522 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. 20203100
3L0J Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand X-RAY DIFFRACTION 2.40 29936.13 253 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. 20203100
3L0E X-ray crystal structure of a Potent Liver X Receptor Modulator X-RAY DIFFRACTION 2.30 30738.72 265 Discovery of tertiary sulfonamides as potent liver X receptor antagonists. 20345102
3KYT Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand X-RAY DIFFRACTION 2.35 30203.46 255 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. 20203100
3KWY Crystal structure of RXRalpha ligand binding domain in complex with triphenyltin and a coactivator fragment X-RAY DIFFRACTION 2.30 29258.63 257 A structural view of nuclear hormone receptor: endocrine disruptor interactions. 20063036
3KMG The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide X-RAY DIFFRACTION 2.10 68882.54 598 Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators
3KFC Complex Structure of LXR with an agonist X-RAY DIFFRACTION 2.40 117560.32 1012 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. 19932617
3KDU Crystal structure of peroxisome proliferator-activatedeceptor alpha (PPARalpha) complex with N-3-((2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy)benzyl)-N-((4-methylphenoxy)carbonyl)glycine X-RAY DIFFRACTION 2.07 63675.33 554 Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). 20218621
3KDT Crystal structure of peroxisome proliferator-activatedeceptor alpha (PPARalpha) complex with N-3-((2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy)benzyl)-N-(methoxycarbonyl)glycine X-RAY DIFFRACTION 2.70 63523.14 554 Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). 20218621
3K8S Crystal Structure of PPARg in complex with T2384 X-RAY DIFFRACTION 2.55 63898.34 544 T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties 18263587
3K6P Estrogen Related Receptor alpha in Complex with an Ether Based Ligand X-RAY DIFFRACTION 2.00 27586.98 248 Development of Diaryl Ether based ligands for Estrogen Related Receptor alpha as Potential Anti-Diabetic Agents.
3IPU X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha X-RAY DIFFRACTION 2.40 72496.78 616 X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. 20382159
3IPS X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha X-RAY DIFFRACTION 2.26 72513.71 616 X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. 20382159
3IPQ X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha X-RAY DIFFRACTION 2.00 36351.00 308 X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. 20382159
3IA6 X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist X-RAY DIFFRACTION 2.31 62827.56 542 Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists. 19783444
3HVL Tethered PXR-LBD/SRC-1p complexed with SR-12813 X-RAY DIFFRACTION 2.10 79377.87 688 Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability 18456871
3HOD Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid X-RAY DIFFRACTION 2.10 65394.20 572 New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function 19775169
3HO0 Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid X-RAY DIFFRACTION 2.60 65408.23 572 New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function 19775169
3HC6 FXR with SRC1 and GSK088 X-RAY DIFFRACTION 3.20 30381.72 253 FXR agonist activity of conformationally constrained analogs of GW 4064. 19586769
3HC5 FXR with SRC1 and GSK826 X-RAY DIFFRACTION 2.60 30428.80 253 FXR agonist activity of conformationally constrained analogs of GW 4064. 19586769
3H0A Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist X-RAY DIFFRACTION 2.10 60300.57 524 Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. 19464171
3GZ9 Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist X-RAY DIFFRACTION 2.00 31487.78 269 Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. 19464171
3GWX MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS X-RAY DIFFRACTION 2.40 62639.51 542 Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. 10198642
3GD2 isoxazole ligand bound to farnesoid X receptor (FXR) X-RAY DIFFRACTION 3.20 28678.30 240 Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064. 19410460
3GBK Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with a Potent and Selective Agonist X-RAY DIFFRACTION 2.30 62586.35 542 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists 19301897
3G9E Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II diabetes X-RAY DIFFRACTION 2.30 32906.52 284 Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. 19349176
3G8I Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes X-RAY DIFFRACTION 2.20 32670.34 283 Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. 19349176
3FXV Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist X-RAY DIFFRACTION 2.26 29311.77 246 Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist 19328688
3FUR Crystal Structure of PPARg in complex with INT131 X-RAY DIFFRACTION 2.30 32987.64 284 INT131: a selective modulator of PPAR gamma 19452630
3FUG Crystal Structure of the Retinoid X Receptor Ligand Binding Domain Bound to the Synthetic Agonist 3-[4-Hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-phenyl]acrylic Acid X-RAY DIFFRACTION 2.00 28756.55 253 Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. 19408900
3FS1 Crystal structure of HNF4a LBD in complex with the ligand and the coactivator PGC-1a fragment X-RAY DIFFRACTION 2.20 27005.74 239 Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation 19846556
3FLI Discovery of XL335, a Highly Potent, Selective and Orally-Active Agonist of the Farnesoid X Receptor (FXR) X-RAY DIFFRACTION 2.00 27385.57 231 Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). 19159286
3FEJ Design and biological evaluation of novel, balanced dual PPARa/g agonists X-RAY DIFFRACTION 2.01 32900.94 284 Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists 19326383
3FEI Design and biological evaluation of novel, balanced dual PPARa/g agonists X-RAY DIFFRACTION 2.40 32363.46 280 Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists 19326383
3FC6 hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875 X-RAY DIFFRACTION 2.06 117308.88 1016 Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. 19167885
3FAL humanRXR alpha & mouse LXR alpha complexed with Retenoic acid and GSK2186 X-RAY DIFFRACTION 2.36 117066.44 1016 Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. 18800767
3ET3 Structure of PPARgamma with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid X-RAY DIFFRACTION 1.95 35663.65 308 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent 19116277
3ET2 Structure of PPARdelta with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid X-RAY DIFFRACTION 2.24 66880.21 574 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent 19116277
3ET1 Structure of PPARalpha with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid X-RAY DIFFRACTION 2.50 70458.44 614 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent 19116277
3ET0 Structure of PPARgamma with 3-(5-Methoxy-1H-indol-3-yl)-propionic acid X-RAY DIFFRACTION 2.40 67151.40 584 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent 19116277
3E94 Crystal structure of RXRalpha ligand binding domain in complex with tributyltin and a coactivator fragment X-RAY DIFFRACTION 1.90 29198.66 257 Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors 19270714
3E00 Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with GW9662, 9-cis Retinoic Acid and NCOA2 Peptide X-RAY DIFFRACTION 3.10 116042.15 952 Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. 19043829
3DZY Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with Rosiglitazone, 9-cis Retinoic Acid and NCOA2 Peptide X-RAY DIFFRACTION 3.10 116122.89 952 Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. 19043829
3DZU Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with BVT.13, 9-cis Retinoic Acid and NCOA2 Peptide X-RAY DIFFRACTION 3.20 116169.68 952 Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. 19043829
3DY6 PPARdelta complexed with an anthranilic acid partial agonist X-RAY DIFFRACTION 2.90 63034.47 542 Discovery of a novel class of PPARdelta partial agonists 18722772
3DCU FXR with SRC1 and GSK8062 X-RAY DIFFRACTION 2.95 30692.26 256 Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. 18621523
3DCT FXR with SRC1 and GW4064 X-RAY DIFFRACTION 2.50 30702.69 256 Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. 18621523
3D6D Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer) X-RAY DIFFRACTION 2.40 65380.17 572 Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design 19053776
3D5F Crystal Structure of PPAR-delta complex X-RAY DIFFRACTION 2.20 61942.49 534 PPAR-Delta Activation Contributes to Neuroprotectio Against Thapsigargin-Induced SH-SY5Y Cell Death
3CWD Molecular recognition of nitro-fatty acids by PPAR gamma X-RAY DIFFRACTION 2.40 66848.59 572 Molecular recognition of nitrated fatty acids by PPAR gamma. 18604218
3CS8 Structural and Biochemical Basis for the Binding Selectivity of PPARg to PGC-1a X-RAY DIFFRACTION 2.30 33296.90 287 Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha. 18469005
3CQV Crystal structure of Reverb beta in complex with heme X-RAY DIFFRACTION 1.90 23486.70 199 The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. 19243223
3CDS Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue) X-RAY DIFFRACTION 2.65 65332.13 572 Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design 19053776
3CDP Crystal structure of PPAR-gamma LBD complexed with a partial agonist, analogue of clofibric acid X-RAY DIFFRACTION 2.80 65338.52 572 Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 22341573
3BEJ Structure of human FXR in complex with MFA-1 and co-activator peptide X-RAY DIFFRACTION 1.90 62313.66 526 Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. 18391212
3BC5 X-ray crystal structure of human ppar gamma with 2-(5-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2h-1,2,3-triazol-4-yl)acetic acid X-RAY DIFFRACTION 2.27 34246.95 296 Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. 19201606
3B3K Crystal structure of the complex between PPARgamma and the full agonist LT175 X-RAY DIFFRACTION 2.60 65380.17 572 Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design 19053776
3B1M Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator Cerco-A X-RAY DIFFRACTION 1.60 34993.85 302 Pharmacology and in Vitro Profiling of a Novel Peroxisome Proliferator-Activated Receptor gamma Ligand, Cerco-A 21720019
3B0W Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with digoxin X-RAY DIFFRACTION 2.20 58177.90 486 Structural Basis of Digoxin That Antagonizes ROR{gamma}t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production 21733845
3B0R Human PPAR gamma ligand binding dmain complexed with GW9662 in a covalent bonded form X-RAY DIFFRACTION 2.15 63126.56 548 Human PPAR gamma ligand binding dmain complexed with GW9662 in a covalent bonded form
3B0Q Human PPAR gamma ligand binding domain in complex with MCC555 X-RAY DIFFRACTION 2.10 62954.62 548 Crystal structure of human PPAR gamma in complex with MCC555
3AN4 Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R X-RAY DIFFRACTION 2.30 65627.55 572 Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship 21128600
3AN3 Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO3S X-RAY DIFFRACTION 2.30 65627.55 572 Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship 21128600
3ADX Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233 X-RAY DIFFRACTION 1.95 66405.08 574 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
3ADW Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate and 15-oxo-eicosatetraenoic acid X-RAY DIFFRACTION 2.07 66230.32 574 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
3ADV Human PPARgamma ligand-binding domain in complex with serotonin X-RAY DIFFRACTION 2.27 65916.85 574 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
3ADU Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate X-RAY DIFFRACTION 2.77 66414.26 574 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
3ADT Human PPARgamma ligand-binding domain in complex with 5-hydroxy-indole acetate X-RAY DIFFRACTION 2.70 65770.57 574 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
3ADS Human PPARgamma ligand-binding domain in complex with indomethacin X-RAY DIFFRACTION 2.25 66461.58 574 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
2ZY0 Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide X-RAY DIFFRACTION 2.90 57669.37 506 Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology 19496083
2ZXZ Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide X-RAY DIFFRACTION 3.00 28802.54 253 Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology 19496083
2ZVT Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2 X-RAY DIFFRACTION 1.90 65662.68 572 Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands 19101554
2ZNQ Human PPRR delta ligand binding domain in complex with a synthetic agonist TIPP401 X-RAY DIFFRACTION 2.65 64467.28 552 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures 19622862
2ZNP Human PPRR delta ligand binding domain in complex with a synthetic agonist TIPP204 X-RAY DIFFRACTION 3.00 64551.44 552 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures 19622862
2ZNO Human PPRR gamma ligand binding domain in complex with a synthetic agonist TIPP703 X-RAY DIFFRACTION 2.40 66069.16 572 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures 19622862
2ZNN Human PPRR alpha ligand binding domain in complex with a synthetic agonist TIPP703 X-RAY DIFFRACTION 2.01 31359.98 273 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures 19622862
2ZKC Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol Z X-RAY DIFFRACTION 1.70 28063.84 244 Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol Z
2ZK6 Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with C8-BODIPY X-RAY DIFFRACTION 2.41 65870.41 572 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites 20717101
2ZK5 Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with nitro-233 X-RAY DIFFRACTION 2.45 65664.40 572 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids 18977231
2ZK4 Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo-eicosatetraenoic acid X-RAY DIFFRACTION 2.57 65698.71 572 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids 18977231
2ZK3 Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 8-oxo-eicosatetraenoic acid X-RAY DIFFRACTION 2.58 65698.71 572 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids 18977231
2ZK2 Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with glutathion conjugated 15-deoxy-delta12,14-prostaglandin J2 X-RAY DIFFRACTION 2.26 65685.56 572 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids 18977231
2ZK1 Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2 X-RAY DIFFRACTION 2.61 65694.68 572 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids 18977231
2ZAS Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol A derivative X-RAY DIFFRACTION 2.00 27915.69 244 ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner 18582436
2Z4J Crystal structure of AR LBD with SHP peptide NR Box 2 X-RAY DIFFRACTION 2.60 30364.02 258 Interaction between the androgen receptor and a segment of its corepressor SHP 18007036
2YFE Ligand binding domain of human PPAR gamma in complex with amorfrutin 1 X-RAY DIFFRACTION 2.00 66069.04 574 Amorfrutins are Potent Antidiabetic Dietary Natural Products 22509006
2XYX NOVEL SULFONYLTHIADIAZOLES WITH AN UNUSUAL BINDING MODE AS PARTIAL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) GAMMA-DELTA AGONISTS WITH HIGH POTENCY AND IN-VIVO EFFICACY X-RAY DIFFRACTION 2.70 67589.66 576 Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy 21400663
2XYW NOVEL SULFONYLTHIADIAZOLES WITH AN UNUSUAL BINDING MODE AS PARTIAL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) GAMMA-DELTA AGONISTS WITH HIGH POTENCY AND IN-VIVO EFFICACY X-RAY DIFFRACTION 3.14 67655.86 576 Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy 21400663
2XYJ NOVEL SULFONYLTHIADIAZOLES WITH AN UNUSUAL BINDING MODE AS PARTIAL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) GAMMA-DELTA AGONISTS WITH HIGH POTENCY AND IN-VIVO EFFICACY X-RAY DIFFRACTION 2.30 68211.32 576 Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy 21400663
2XKW LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE X-RAY DIFFRACTION 2.02 63949.02 548 Binding Diversity of Pioglitazone by Peroxisome Proliferator-Activated Receptor-Gamma
2VV4 hPPARgamma Ligand binding domain in complex with 6-oxoOTE X-RAY DIFFRACTION 2.35 63534.47 552 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids 19172745
2VV3 hPPARgamma Ligand binding domain in complex with 4-oxoDHA X-RAY DIFFRACTION 2.85 63244.09 552 Structural Basis for the Activation of Ppargamma by Oxidized Fatty Acids. 19172745
2VV2 hPPARgamma Ligand binding domain in complex with 5-HEPA X-RAY DIFFRACTION 2.75 63854.97 552 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids 19172745
2VV1 hPPARgamma Ligand binding domain in complex with 4-HDHA X-RAY DIFFRACTION 2.20 63604.59 552 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids 19172745
2VV0 hPPARgamma Ligand binding domain in complex with DHA X-RAY DIFFRACTION 2.55 63556.59 552 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids 19172745
2VST hPPARgamma Ligand binding domain in complex with 13-(S)-HODE X-RAY DIFFRACTION 2.35 63492.50 552 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids 19172745
2VSR hPPARgamma Ligand binding domain in complex with 9-(S)-HODE X-RAY DIFFRACTION 2.05 63788.95 552 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids 19172745
2V7C CRYSTAL STRUCTURE OF REV-ERB BETA X-RAY DIFFRACTION 2.40 44639.00 388 Structural Insight Into the Constitutive Repression Function of the Nuclear Receptor Rev-Erbbeta 17870090
2REW Crystal Structure of PPARalpha ligand binding domain with BMS-631707 X-RAY DIFFRACTION 2.35 32691.33 277 Discovery of Azetidinone Acids as Conformationally-Constrained Dual (alpha/gamma) PPAR Activators
2QNV Crystal Structure of the Pregnane X Receptor bound to Colupulone X-RAY DIFFRACTION 2.80 36681.76 316 Crystal Structure of the Pregnane X Receptor bound to Colupulone
2Q8S X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist X-RAY DIFFRACTION 2.30 62409.10 542 Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies. 18394907
2Q6S 2.4 angstrom crystal structure of PPAR gamma complexed to BVT.13 without co-activator peptides X-RAY DIFFRACTION 2.40 62995.41 548 Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism 17937915
2Q6R Crystal structure of PPAR gamma complexed with partial agonist SF147 X-RAY DIFFRACTION 2.41 63439.03 548 Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism 17937915
2Q61 Crystal Structure of PPARgamma ligand binding domain bound to partial agonist SR145 X-RAY DIFFRACTION 2.20 63378.97 548 Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism 17937915
2Q5S Crystal Structure of PPARgamma bound to partial agonist nTZDpa X-RAY DIFFRACTION 2.05 63447.86 548 Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism 17937915
2Q5P Crystal Structure of PPARgamma bound to partial agonist MRL24 X-RAY DIFFRACTION 2.30 63646.19 548 Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism 17937915
2Q5G Ligand binding domain of PPAR delta receptor in complex with a partial agonist X-RAY DIFFRACTION 2.70 66171.06 566 Design of a partial PPARdelta agonist. 17560785
2Q59 Crystal Structure of PPARgamma LBD bound to full agonist MRL20 X-RAY DIFFRACTION 2.20 63722.29 548 Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism 17937915
2Q3Y Ancestral Corticiod Receptor in Complex with DOC X-RAY DIFFRACTION 2.40 30406.42 259 Crystal structure of an ancient protein: evolution by conformational epistasis 17702911
2PRG LIGAND-BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA X-RAY DIFFRACTION 2.30 72105.75 630 Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. 9744270
2POB PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709 X-RAY DIFFRACTION 2.30 62854.58 544 Cocrystal structure guided array synthesis of PPARgamma inverse agonists 17533125
2PJL Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism X-RAY DIFFRACTION 2.30 54699.58 494 Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. 17556356
2P7Z Estrogen Related Receptor Gamma in complex with 4-hydroxy-tamoxifen X-RAY DIFFRACTION 2.50 28774.62 251 Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. 17964775
2P7G X-ray Structure of Estrogen Related Receptor g in complex with Bisphenol A. X-RAY DIFFRACTION 2.10 28638.38 251 Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. 17964775
2P7A Crystal Structure of Estrogen Related Receptor g in complex with 3-methyl phenol X-RAY DIFFRACTION 2.30 28529.68 251 Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. 17964775
2P54 a crystal structure of PPAR alpha bound with SRC1 peptide and GW735 X-RAY DIFFRACTION 1.79 32267.92 279 Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents. 17243659
2P4Y Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator X-RAY DIFFRACTION 2.25 64459.82 554 The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities. 17940191
2P1V Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-propoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2 X-RAY DIFFRACTION 2.20 28844.62 253 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. 17947383
2P1U Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-ethoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2 X-RAY DIFFRACTION 2.20 28830.59 253 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. 17947383
2P1T Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-methoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2 X-RAY DIFFRACTION 1.80 28816.56 253 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. 17947383
2OM9 Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma X-RAY DIFFRACTION 2.80 130144.85 1112 Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor gamma 17462987
2O9I Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317 X-RAY DIFFRACTION 2.80 72073.50 616 Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. 17215127
2NPA the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid X-RAY DIFFRACTION 2.30 65597.02 570 Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists 17157019
2NLL RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA X-RAY DIFFRACTION 1.90 31358.03 205 Structural determinants of nuclear receptor assembly on DNA direct repeats. 7746322
2J14 3,4,5-TRISUBSTITUTED ISOXAZOLES AS NOVEL PPARDELTA AGONISTS: PART2 X-RAY DIFFRACTION 2.80 66384.92 570 3,4,5-Trisubstituted Isoxazoles as Novel Ppardelta Agonists. Part 2 16931011
2I4Z Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours. X-RAY DIFFRACTION 2.25 65514.39 572 Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands 17403688
2I4P Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). Structure obtained from crystals of the apo-form soaked for 30 days. X-RAY DIFFRACTION 2.10 65514.39 572 Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. 17403688
2I4J Crystal structure of the complex between PPARgamma and the agonist LT160 (ureidofibrate derivative) X-RAY DIFFRACTION 2.10 65514.39 572 Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands 17403688
2HWR Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists X-RAY DIFFRACTION 2.34 62544.27 542 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists 17034149
2HWQ Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists X-RAY DIFFRACTION 1.97 62516.21 542 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists 17034149
2HFP Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands X-RAY DIFFRACTION 2.00 36028.83 303 Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. 16919947
2GTK Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists X-RAY DIFFRACTION 2.10 32591.61 281 Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists 16737814
2GPV Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide X-RAY DIFFRACTION 2.85 166632.75 1446 X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. 16990259
2GPU Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen X-RAY DIFFRACTION 1.70 26472.12 230 X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. 16990259
2GPP Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716 X-RAY DIFFRACTION 2.60 58120.20 510 X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. 16990259
2G0H Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities X-RAY DIFFRACTION 2.30 63065.51 542 Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities 16640330
2G0G Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities X-RAY DIFFRACTION 2.54 62412.05 542 Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities 16640330
2FVJ A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro X-RAY DIFFRACTION 1.99 33103.78 284 A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro 16373399
2F4B Crystal structure of the ligand binding domain of human PPAR-gamma in complex with an agonist X-RAY DIFFRACTION 2.07 62516.21 542 Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies 16451087
2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 X-RAY DIFFRACTION 2.30 130377.73 1130 Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. 16307879
2E2R Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol A X-RAY DIFFRACTION 1.60 28115.87 244 Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR{gamma} 17761695
2BAW Human Nuclear Receptor-Ligand Complex 1 X-RAY DIFFRACTION 2.30 62259.22 534 Reevaluation of the PPAR-beta/delta Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form 16387648
2B50 Human Nuclear Receptor-Ligand Complex 2 X-RAY DIFFRACTION 2.00 63262.38 544 Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids 16405912
2AWH Human Nuclear Receptor-Ligand Complex 1 X-RAY DIFFRACTION 2.00 62489.42 536 Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids 16405912
2ATH Crystal structure of the ligand binding domain of human PPAR-gamma im complex with an agonist X-RAY DIFFRACTION 2.28 62947.50 542 Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities 16366601
2ACL Liver X-Receptor alpha Ligand Binding Domain with SB313987 X-RAY DIFFRACTION 2.80 222169.50 1928 Discovery of substituted maleimides as liver x receptor agonists and determination of a ligand-bound crystal structure. 16107141
2A66 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter X-RAY DIFFRACTION 2.20 20725.16 137 Crystal Structure of the Human LRH-1 DBD-DNA Complex Reveals Ftz-F1 Domain Positioning is Required for Receptor Activity. 16289203
1ZGY Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP X-RAY DIFFRACTION 1.80 33302.05 289 Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. 15976031
1ZEO Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist X-RAY DIFFRACTION 2.50 63612.32 554 Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity 15974597
1ZDU The Crystal Structure of Human Liver Receptor Homologue-1 X-RAY DIFFRACTION 2.50 32008.23 267 The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1 15897460
1ZDT The Crystal Structure of Human Steroidogenic Factor-1 X-RAY DIFFRACTION 2.10 59604.09 506 The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1 15897460
1YUC Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP X-RAY DIFFRACTION 1.90 63515.75 538 Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP 15723037
1YOW human Steroidogenic Factor 1 LBD with bound Co-factor Peptide X-RAY DIFFRACTION 3.00 29500.75 253 Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1 15707893
1YOK crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol X-RAY DIFFRACTION 2.50 33965.60 284 Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. 15707893
1Y0S Crystal structure of PPAR delta complexed with GW2331 X-RAY DIFFRACTION 2.65 65162.62 544 Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) Generates a PPAR delta Phenotype 10809235
1XVP crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO X-RAY DIFFRACTION 2.60 117035.46 1016 A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer. 15610735
1XV9 crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione. X-RAY DIFFRACTION 2.70 116915.20 1016 A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer. 15610735
1XLS Crystal structure of the mouse CAR/RXR LBD heterodimer bound to TCPOBOP and 9cRA and a TIF2 peptide containg the third LXXLL motifs X-RAY DIFFRACTION 2.96 235876.81 2040 The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. 15610733
1WM0 PPARgamma in complex with a 2-BABA compound X-RAY DIFFRACTION 2.90 35382.91 306 A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects 15258145
1VJB crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen X-RAY DIFFRACTION 3.20 57549.24 502 Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity. 15161930
1UPW CRYSTAL STRUCTURE OF THE HUMAN LIVER X RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST X-RAY DIFFRACTION 2.40 29898.13 257 Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist 14643652
1UPV CRYSTAL STRUCTURE OF THE HUMAN LIVER X RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST X-RAY DIFFRACTION 2.10 29898.13 257 Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist 14643652
1UHL Crystal structure of the LXRalfa-RXRbeta LBD heterodimer X-RAY DIFFRACTION 2.90 57619.61 498 Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation 12970175
1SKX Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin X-RAY DIFFRACTION 2.80 36858.85 313 Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin 15705662
1S9Q crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen X-RAY DIFFRACTION 2.20 58366.40 502 Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity. 15161930
1S9P crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with diethylstilbestrol X-RAY DIFFRACTION 2.13 104222.22 908 Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity. 15161930
1S0X Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A X-RAY DIFFRACTION 2.20 31981.22 270 Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A 14722075
1RDT Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer X-RAY DIFFRACTION 2.40 65772.68 574 Structure-based design of potent retinoid X receptor alpha agonists. 15056000
1PZL Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide X-RAY DIFFRACTION 2.10 28578.47 251 Structural Basis for HNF-4alpha Activation by Ligand and Coactivator Binding 14982928
1PQC HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 X-RAY DIFFRACTION 2.80 118155.33 1012 The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. 12819202
1PQ9 HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 COMPLEX X-RAY DIFFRACTION 2.10 118227.39 1012 The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. 12819202
1PQ6 HUMAN LXR BETA HORMONE RECEPTOR / GW3965 COMPLEX X-RAY DIFFRACTION 2.40 118096.37 1012 The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. 12819202
1P8D X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol X-RAY DIFFRACTION 2.80 63875.85 550 X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. 12736258
1OVL Crystal Structure of Nurr1 LBD X-RAY DIFFRACTION 2.20 186167.27 1626 Structure and Function of Nurr1 identifies a Class of Ligand-Independent Nuclear Receptors 12774125
1OSH A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR X-RAY DIFFRACTION 1.80 27583.96 232 A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR 12718892
1NYX Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist X-RAY DIFFRACTION 2.65 63549.28 552 Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar 12672231
1NRL Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813 X-RAY DIFFRACTION 2.00 79183.84 682 Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor 12909012
1N83 Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol X-RAY DIFFRACTION 1.63 31901.16 270 X-ray Structure of hROR(alpha) LBD at 1.63A: Structural and Functional data that Cholesterol or a Cholesterol derivative is the natural ligand of ROR(alpha) 12467577
1MZN CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE X-RAY DIFFRACTION 1.90 115262.22 1012 Molecular Recognition of Agonist Ligands by RXRs 11981034
1MVC Crystal structure of the human RXR alpha ligand binding domain bound to the synthetic agonist compound BMS 649 and a coactivator peptide X-RAY DIFFRACTION 1.90 28815.55 253 Molecular Recognition of Agonist Ligands by RXRs 11981034
1MV9 Crystal Structure of the human RXR alpha ligand binding domain bound to the eicosanoid DHA (Docosa Hexaenoic Acid) and a coactivator peptide X-RAY DIFFRACTION 1.90 28764.57 253 Molecular Recognition of Agonist Ligands by RXRs 11981034
1M13 Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort X-RAY DIFFRACTION 2.15 36817.99 316 2.1 A Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin 12578355
1KNU LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST X-RAY DIFFRACTION 2.50 63046.88 548 Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity 11831892
1KKQ Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif X-RAY DIFFRACTION 3.00 133212.66 1152 Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. 11845213
1K7L The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide. X-RAY DIFFRACTION 2.50 142872.45 1236 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. 11698662
1K74 The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides. X-RAY DIFFRACTION 2.30 65518.29 571 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. 11698662
1ILH Crystal Structure of Human Pregnane X Receptor Ligand Binding Domain Bound to SR12813 X-RAY DIFFRACTION 2.76 36785.74 316 The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. 11408620
1I7I CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242 X-RAY DIFFRACTION 2.35 67236.33 584 Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. 11587644
1I7G CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ 242 X-RAY DIFFRACTION 2.20 33631.12 287 Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. 11587644
1H9U THE STRUCTURE OF THE HUMAN RETINOID-X-RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SPECIFIC SYNTHETIC AGONIST LG100268 X-RAY DIFFRACTION 2.70 101130.91 896 The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12 11782480
1GWX MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS X-RAY DIFFRACTION 2.50 63198.40 542 Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. 10198642
1GA5 CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT X-RAY DIFFRACTION 2.40 68891.28 456 DNA Deformability as a Recognition Feature in the RevErb Response Element 11669620
1G5Y THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER. X-RAY DIFFRACTION 2.00 107272.88 952 Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix. 10970886
1FM9 THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES. X-RAY DIFFRACTION 2.10 64221.82 560 Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. 10882139
1FM6 THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES. X-RAY DIFFRACTION 2.10 128065.25 1120 Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. 10882139
1FBY CRYSTAL STRUCTURE OF THE HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO 9-CIS RETINOIC ACID X-RAY DIFFRACTION 2.25 54111.08 478 Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. 10835357
1A6Y REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX X-RAY DIFFRACTION 2.30 34445.65 228 Structural elements of an orphan nuclear receptor-DNA complex. 9660968
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