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S.No. Small Molecules Pubmed Web of Science Target Off Targets PMID System Relevant Articles
1 Rapamycin 1788 1769 Mechanistic target of rapamycin kinase (MTOR) Eukaryotic translation initiation factor 4E (EIF4E), nuclear receptor subfamily 1 group I member 2 (NR1I2) 15833867 Human CANCER RESEARCH 2005
            16322256 Human CANCER RESEARCH 2005
            19773438 Human CANCER RESEARCH 2009
            20168088 Human AUTOPHAGY 2010
            20404486 Human AUTOPHAGY 2010
            23322078 Human AUTOPHAGY 2013
            24917666 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 2014
            25884947 Mouse PLOS ONE 2015
            27846905 Human STEM CELL RESEARCH & THERAPY 2016
            28371119 Human AGING CELL 2017
                 
2 Chloroquine 1225 1093 Lysosomal pH Histamine receptor H3 (HRH3), Voltage-gated calcium channel, Histamine N-methyltransferase (HNMT) 21148553 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2011
            20980833 Rat, Mouse, human AUTOPHAGY 2011
            20543569 Human AUTOPHAGY 2010
            19305149 Mouse AUTOPHAGY 2009
            18253089 Mouse, Human AUTOPHAGY 2008
            18216495 Mouse AUTOPHAGY 2008
            11983070 Rat JOURNAL OF BIOCHEMISTRY 2002
            21536669 Human, Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2011
            21808151 Mouse AUTOPHAGY 2011
            22252008 Mouse AUTOPHAGY 2012
                 
3 BafilomycinA1 573 411 Lysosomal pH   14713959 Human CELL DEATH AND DIFFERENTIATION 2004
            19305162 Rat AUTOPHAGY 2009
            20104024 Human AUTOPHAGY 2010
            21536669 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2011
            23109342 Human, Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2012
            23212917 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2013
            25512644 Human, Mouse HAEMATOLOGICA 2014
            26337205 Human ONCOTARGET 2015
            27845389 Human SCIENTIFIC REPORTS 2016
            28717222 Human SCIENTIFIC REPORTS 2017
                 
4 Hydrogen_peroxide 308 328     22577861 Mouse AGING CELL 2012
            22889724 Mouse AUTOPHAGY 2012
            23894332 Rat PLOS ONE 2013
            23811287 Human CANCER LETTERS 2013
            24434520 Rat CELL DEATH & DISEASE 2014
            25471085 Mouse FREE RADICAL RESEARCH 2015
            26046590 Mouse AUTOPHAGY 2015
            26469953 Human, Rat CELL DEATH & DISEASE 2015
            27427974 Human, Mouse AUTOPHAGY 2016
            27607582 Human CELL DEATH & DISEASE 2016
                 
5 Wortmannin 250 223 Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) Mechanistic target of rapamycin kinase (MTOR), DNA-dependent protein kinase (DNA-PK), Myosin light chain kinase(MLCK) 10329731 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1999
            18505729 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2008
            20104024 Human AUTOPHAGY 2010
            21266992 Mouse NATURE COMMUNICATIONS 2010
            22240590 Mouse AUTOPHAGY 2012
            22972933 Human, Mouse JOURNAL OF IMMUNOLOGY 2012
            23586593 Human JOURNAL OF NEUROCHEMISTRY 2013
            25483963 Mouse AUTOPHAGY 2014
            26043790 Rat AUTOPHAGY 2015
            28337019 Human SCIENTIFIC REPORTS 2017
                 
6 LY294002 180 182 Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) DNA-dependent protein kinase (DNA-PK) 15833867 Human CANCER RESEARCH 2005
            18611860 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2008
            19098447 Human AUTOPHAGY 2009
            20876581 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2010
            25738356 Human ONCOTARGET 2015
            26311737 Human ONCOTARGET 2015
            27029407 Mouse SCIENTIFIC REPORTS 2016
            27240523 Human SCIENTIFIC REPORTS 2016
            28731179 Human ONCOLOGY REPORTS 2017
                 
7 MG132 167 121 Calpain (CAPN) HDAC6 16413676 Human CANCER LETTERS 2006
            20104019 Human AUTOPHAGY 2010
            24602982 Human NEUROSCIENCE LETTERS 2014
            24805111 Human CELL BIOLOGY INTERNATIONAL 2014
            25540198 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2015
            25434876 Mouse MOLECULAR MEDICINE REPORTS 2015
            26052093 Human CANCER LETTERS 2015
            27766434 Human APOPTOSIS 2017
                 
8 3MA 156 125 Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) Mechanistic target of rapamycin kinase (MTOR) 20168088 Rat AUTOPHAGY 2010
            21593791 Human CELL DEATH & DISEASE 2011
            22694815 Mouse AUTOPHAGY 2012
            22722716 Human AUTOPHAGY 2012
            24492484 Human, Mouse AUTOPHAGY 2014
            26102061 Mouse, Rat AUTOPHAGY 2015
            26553601 Human AUTOPHAGY 2015
            26237084 Rat AUTOPHAGY 2016
            28205545 Rat SCIENTIFIC REPORTS 2017
            28526886 Mouse SCIENTIFIC REPORTS 2017
                 
9 Hydroxychloroquine 144 136 Lysosomal pH   27807188 Human MOLECULAR CANCER RESEARCH 2017
            27683126 Human ONCOTARGET 2016
            27463016 Human ONCOTARGET 2016
                 
10 Curcumin 140 183 VDR Retinoic Acid Receptor (RAR) 23182879 Human AUTOPHAGY 2013
            22622204 Human AUTOPHAGY 2012
            28498433 Human ONCOLOGY REPORTS 2017
            28159921 Mouse ONCOTARGET 2017
            27689333 Human ONCOTARGET 2016
            27626169 Human ONCOTARGET 2016
            27502897 Human SCIENTIFIC REPORTS 2016
            26573768 Human ONCOLOGY REPORTS 2016
            26752181 Human PLOS ONE 2016
                 
11 Cycloheximide 140 82 HIF1A   645821 Rat AM J PATHOL. 1978
            1844304 Mouse ACTA BIOL HUNG. 1991
            553561 Rat BOLL SOC ITAL BIOL SPER. 1979
            1789148 Mouse ACTA MORPHOL HUNG. 1991;
            3941538 Rat LAB INVEST. 1986
                 
12 Temozolomide 139 211     14713959 Human CELL DEATH AND DIFFERENTIATION 2004
            16946731 Human CELL DEATH AND DIFFERENTIATION 2007
            19190119 Human MOLECULAR CANCER THERAPEUTICS 2009
            20587533 Human MOLECULAR CANCER RESEARCH 2010
            23128449 Human ONCOLOGY REPORTS 2013
            23546299 Human MOLECULAR THERAPY 2013
            24737504 Human MOLECULAR MEDICINE REPORTS 2014
            25646660 Human MOLECULAR MEDICINE REPORTS 2015
            26976976 Mouse ANTICANCER RESEARCH 2016
            28693171 Human ONCOLOGY LETTERS 2017
                 
13 Tamoxifen 135 149 Lysosomal pH Progesterone receptor (PGR), Estrogen receptor (ESR) 16990848 Human CELL DEATH AND DIFFERENTIATION 2007
            19221464 Human AUTOPHAGY 2009
            19487283 Human CANCER RESEARCH 2009
            19521424 Human CELL DEATH AND DIFFERENTIATION 2009
            20594311 Human BREAST CANCER RESEARCH 2010
            22895056 Human AUTOPHAGY 2012
            25738357 Human ONCOTARGET 2015
            27027343 Human ONCOTARGET 2016
            27526942 Human JOURNAL OF BIOMEDICAL SCIENCE 2016
            28186242 Mouse JOURNAL OF INFECTIOUS DISEASES 2017
                 
14 Dorsomorphin 133 139 Protein kinase AMP-activated (PRKA) TGF-beta receptor type II, fms related tyrosine kinase 1 (FLT1), tyrosine-protein kinase SRC, Activin A receptor type 1 (ACVR1) 28404910 Human ONCOTARGET 2017
            26876211 Human, Mouse ONCOGENE 2016
            27533078 Mouse AUTOPHAGY 2016
            24145604 Human AUTOPHAGY 2013
            23447692 Mouse JOURNAL OF IMMUNOLOGY 2013
            21521688 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 2011
            20980833 Human AUTOPHAGY 2011
            21127263 Human PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010
            16990266 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2006
            24080159 Human CELLULAR SIGNALLING 2014
            26029847 Human AUTOPHAGY 2015
            25227893 Human INTERNATIONAL JOURNAL OF CANCER 2015
            24419061 Human MOLECULAR CANCER THERAPEUTICS 2014
            24297300 Human ONCOLOGY REPORTS 2014
                 
15 Tunicamycin 129 131     17135238 Human, Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2007
            17404493 Human AUTOPHAGY 2007
            18356160 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2008
            18604159 Human, Mouse AUTOPHAGY 2008
            20104019 Mouse AUTOPHAGY 2010
            25126734 Rat AUTOPHAGY 2014
            26018731 Human AUTOPHAGY 2015
            28276509 Human SCIENTIFIC REPORTS 2017
            28667325 Human SCIENTIFIC REPORTS 2017
            28537902 Human ONCOTARGET 2017
                 
                 
17 Thapsigargin 117 111 Calcium channel prostaglandin-endoperoxide synthase (PTGS) 17244528 Human, Mouse MOLECULAR CELL 2007
            17135238 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2007
            17256008 Rat CELL DEATH AND DIFFERENTIATION 2007
            18356160 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2008
            20114074 Human, Mouse CELLULAR SIGNALLING 2010
            21700220 Mouse MOLECULAR CELL 2011
            22740450 Human BLOOD 2012
            23970164 Human AUTOPHAGY 2013
            26018731 Human AUTOPHAGY 2015
            28302665 Human BIOLOGY OPEN 2017
                 
18 Vinblastine 109 68 AP-1 MAPK8 28615716 Mouse SCIENTIFIC REPORTS 2017
            23800949 Human AUTOPHAGY 2013
            20864542 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2010
            7759538 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1995
                 
19 Lithium 106 135 Inositol monophosphatase IMPA glycogen synthase kinase 3 beta (GSK3B), adenylate cyclase (ADCY) 16186256 Human JOURNAL OF CELL BIOLOGY 2005
            18340111 Human AUTOPHAGY 2008
            17921520 Human, Mouse HUMAN MOLECULAR GENETICS 2008
            18250315 Mouse PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008
            19183256 Mouse JOURNAL OF NEUROCHEMISTRY 2009
            21364661 Rat CELL DEATH & DISEASE 2010
            21175620 Mouse JOURNAL OF NEUROCHEMISTRY 2011
            22082874 Mouse AUTOPHAGY 2011
            26248051 Mouse PLOS ONE 2015
            26041819 Mouse HUMAN MOLECULAR GENETICS 2015
                 
20 Metformin 98 115 Protein kinase AMP-activated (PRKA) NFKB 21562078 Mouse DIABETES 2011
            22378068 Mouse CELL DEATH & DISEASE 2012
            24644425 Mouse INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 2014
            24966801 Human CANCER CELL INTERNATIONAL 2014
            25936719 Rat METABOLIC BRAIN DISEASE 2015
            26031332 Mouse, Rat MOLECULAR AND CELLULAR BIOLOGY 2015
            27052588 Mouse SCIENTIFIC REPORTS 2016
            28693272 Mouse ONCOLOGY LETTERS 2017
            28560428 Mouse MOLECULAR MEDICINE REPORTS 2017
            28099155 Human ONCOTARGET 2017
                 
21 Leupeptin 95 65 Calpain (CAPN)   21460622 Mouse AUTOPHAGY 2011
            19158494 Rat AUTOPHAGY 2009
            18708438 Rat AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2008
            18424911 Mouse AUTOPHAGY 2008
            11173534 Rat JOURNAL OF BIOCHEMISTRY 2001
            10686581 Rat CELL BIOCHEMISTRY AND FUNCTION 2000
            1918014 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1991
            10329731 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1999
            10837932 Rat TOXICOLOGY 2000
                 
22 Everolimus 91 114 Mechanistic target of rapamycin kinase (MTOR) cytochrome P450 family 3 subfamily A (CYP3A), cytochrome P450 family 3 subfamily A5 (CYP3A5), Eukaryotic translation initiation factor 4E (EIF4E), FK506-binding protein 1B (FKBP1B), NR1I2 28061438 Human ONCOTARGET 2017
            27638766 Mouse BRITISH JOURNAL OF PHARMACOLOGY 2016
            17224626 Mouse AUTOPHAGY 2007
            27421652 Human BMC CANCER 2016
            26814830 Mouse AMERICAN JOURNAL OF TRANSPLANTATION 2016
            23022334 Rat EUROPEAN JOURNAL OF PHARMACOLOGY 2012
            22879389 Human CLINICAL CANCER RESEARCH 2012
            22491797 Human MOLECULAR CANCER THERAPEUTICS 2012
            17047067 Human CANCER RESEARCH 2006
            25866016 Human CANCER BIOLOGY & THERAPY 2015
                 
23 Etoposide 91 89 Protein kinase AMP-activated (PRKA) DNA topoisomerase II (TOP2), cytochrome P450 family 3 subfamily A member 4 (CYP3A34) 21274505 Human INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2011
            23945651 Human NATURE COMMUNICATIONS 2013
            24189100 Mouse AUTOPHAGY 2013
            21915098 Human EMBO JOURNAL 2011
                 
24 Aicar 80 89 Protein kinase AMP-activated (PRKA) Mechanistic target of rapamycin kinase (MTOR) 27244599 Mouse SCIENTIFIC REPORTS 2016
            21992792 Mouse MOLECULAR CANCER THERAPEUTICS 2011
            19844161 Mouse AUTOPHAGY 2009
            16990266 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2006
            9726984 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1998
            22683340 Mouse AMERICAN JOURNAL OF PATHOLOGY 2012
            25009141 Mouse ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2014
            21992792 Mouse MOLECULAR CANCER THERAPEUTICS 2011
            19844161 Mouse AUTOPHAGY 2009
            16990266 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2006
            9726984 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1998
                 
25 Dexamethasone 72 92 Nuclear receptor subfamily 3 group C member 1 (NR3C1) Androgen receptor (AR), nuclear receptor subfamily 3 group C member 2 (NR3C2), Progesterone receptor (PGR), NR1I2 25658432 Rat PLOS ONE 2015
            19855186 Human AUTOPHAGY 2009
            27127181 Mouse ONCOTARGET 2016
            26287374 Human PLOS ONE 2015
            25778879 Human CANCER BIOLOGY & THERAPY 2015
            23978789 Mouse ONCOTARGET 2013
            20814235 Mouse AUTOPHAGY 2010
            18362516 Mouse AUTOPHAGY 2008
                 
26 Spermidine 70 92 Protein tyrosine phosphatase, non-receptor type 2 (PTPN2) STAT1, STAT3, MAPK14 28386016 Mouse CANCER RESEARCH 2017
            28383560 Human, Rat CELL DEATH & DISEASE 2017
            28407698 Rat ONCOTARGET 2017
            26565691 Mouse AUTOPHAGY 2015
            21339330 Human JOURNAL OF CELL BIOLOGY 2011
            19801973 Human NATURE CELL BIOLOGY 2009
                 
27 Vitamin_D3 63 30 Vitamin D receptor (VDR) Cytochrome P450 family 24 subfamily A member 1 (CYP24A1), Androgen Receptor (AR) 18628207 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2008
            19748465 Human CELL HOST & MICROBE 2009
            21454634 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2011
            25773147 Mouse JOURNAL OF NEUROIMMUNOLOGY 2015
            28145056 Mouse OBESITY 2017
                 
28 CyclosporinA 62 63     20136702 Rat JOURNAL OF PINEAL RESEARCH 2010
            22745676 Human PLOS ONE 2012
            22580614 Human ONCOGENE 2013
            25299210 Rat PLOS ONE 2014
            26305401 Human, Mouse AUTOPHAGY 2015
            27664163 Rat JOURNAL OF MOLECULAR NEUROSCIENCE 2017
                 
29 PepstatinA 60 45 Lysosomal pH Beta-secretase (BACE), Renin (REN) 17331981 Mouse HUMAN MOLECULAR GENETICS 2007
            18424912 Human AUTOPHAGY 2008
            18772242 Rat ENDOCRINOLOGY 2009
            21107021 Human AUTOPHAGY 2011
            21299716 Human CANCER SCIENCE 2011
            22441020 Mouse AUTOPHAGY 2012
            24174532 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2013
            26334320 Human ONCOTARGET 2015
            28294183 Rat SCIENTIFIC REPORTS 2017
            28594408 Rat CELL DEATH & DISEASE 2017
                 
30 Pifithrin 56 61 Tumor proteinp53 (TP53) nuclear receptor subfamily 3 group C member 1 (NR3C1) 19305162 Rat AUTOPHAGY 2009
            19337030 Mouse AUTOPHAGY 2009
            21262221 Human EUROPEAN JOURNAL OF PHARMACOLOGY 2011
            23371857 Human MOLECULAR CANCER THERAPEUTICS 2013
            23644056 Rat NEUROSCIENCE 2013
            24044922 Human CELLULAR SIGNALLING 2013
            24874727 Human CELL DEATH & DISEASE 2014
            27273382 Rat SCIENTIFIC REPORTS 2016
            27324771 Human ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2016
            28182713 Human PLOS ONE 2017
                 
31 Temsirolimus 52 56 Mechanistic target of rapamycin kinase (MTOR) nuclear receptor subfamily 1 group I member 2 (NR1I2), Eukaryotic translation initiation factor 4E (EIF4E), cytochrome P450 family 3 subfamily A (CYP3A) 24991838 Human AUTOPHAGY 2014
            23349989 Human PLOS ONE 2013
            22837537 Mouse SCIENCE TRANSLATIONAL MEDICINE 2012
            28033363 Mouse PLOS ONE 2016
            24994750 Human MOLECULAR CANCER RESEARCH 2014
                 
32 Resveratrol 50 71 Protein kinase AMP-activated (PRKA) N-ribosyldihydronicotinamide:quinone reductase 2 (NQO2), Signal transducer and activator of transcription 3 (STAT3) 20103647 Human CANCER RESEARCH 2010
            20080969 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2010
            20966076 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2010
            20852062 Human FASEB JOURNAL 2011
            21778691 Human NEUROSIGNALS 2011
            24145604 Human AUTOPHAGY 2013
            26902888 Human SCIENTIFIC REPORTS 2016
            26619367 Mouse CANCER 2016
            28197628 Human INTERNATIONAL JOURNAL OF ONCOLOGY 2017
            28238848 Rat NEUROSCIENCE 2017
                 
33 Nocodazole 35 22     27213594 Human ONCOTARGET 2016
            23380587 Human AUTOPHAGY 2013
            27798705 Human PLOS ONE 2016
            23090141 Human AUTOPHAGY 2013
            19369338 Human JOURNAL OF VIROLOGY 2009
            12453151 Human, Rat TRAFFIC 2002
            9249006 Rat EUROPEAN JOURNAL OF BIOCHEMISTRY 1997
                 
34 BrefeldinA 30 50     9309391 Rat EUROPEAN JOURNAL OF CELL BIOLOGY 1997
            17135238 Human, Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2007
            23564048 Human ONCOLOGY REPORTS 2013
            25714112 Human AUTOPHAGY 2015
            26245898 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2015
            27091640 Human SCIENTIFIC REPORTS 2016
                 
35 Salubrinal 28 28     18628650 Human AUTOPHAGY 2008
            23593240 Mouse PLOS ONE 2013
            26043790 Mouse, Rat AUTOPHAGY 2015
            27506466 Human SCIENTIFIC REPORTS 2016
            27182794 Human MOLECULAR CARCINOGENESIS 2017
                 
36 Okadaic_acid 27 57     1320371 Rat BIOCHEMICAL JOURNAL 1992
            8393787 Rat EUROPEAN JOURNAL OF BIOCHEMISTRY 1993
            7890712 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1995
            7540986 Rat EXPERIMENTAL CELL RESEARCH 1995
            15461583 Rat BIOCHEMICAL JOURNAL 2005
            18615642 Rat JOURNAL OF NEUROSCIENCE RESEARCH 2008
            23035115 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2012
            22836274 Rat JOURNAL OF NEUROSCIENCE 2012
            26053095 Human ONCOTARGET 2015
                 
37 E64D 26 26 Lysosomal pH Calpain1/2 (CAPN1/2), cathepsins B and H (CTSB and CTSH) 10329731 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1999
            17331981 Mouse HUMAN MOLECULAR GENETICS 2007
            18424912 Human AUTOPHAGY 2008
            19833726 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2009
            21107021 Human AUTOPHAGY 2011
            22441020 Mouse AUTOPHAGY 2012
            22330834 Mouse NEUROSCIENCE 2012
            24174532 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2013
            26334320 Human ONCOTARGET 2015
            27317662 Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2016
                 
38 Genistein 26 42 Epidermal growth factor receptor (EGFR) topo II 7890712 Rat JOURNAL OF BIOLOGICAL CHEMISTRY 1995
            17234261 Human GYNECOLOGIC ONCOLOGY 2007
            24205354 Human PLOS ONE 2013
            24573886 Human MOLECULAR AND CELLULAR BIOCHEMISTRY 2014
            25202045 Human ANTICANCER RESEARCH 2014
            26352862 Human ONCOLOGY REPORTS 2015
                 
39 TrichostatinA 25 27 Histone deacetylases (HDAC)   21367693 Rat PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011
            21491416 Human CANCER 2011
            22186300 Human CANCER LETTERS 2012
            24122231 Human TUMOR BIOLOGY 2014
            27369083 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2016
            28160167 Human CELLULAR ONCOLOGY 2017
                 
40 Capsaicin 23 30 Nuclear factor kappa B (NFKB) Transient receptor potential cation channel subfamily V member 1 (TRPV1), Protein kinase C epsilon (PRKCE) 26351174 Human CELLULAR AND MOLECULAR NEUROBIOLOGY 2016
            26625315 Human ONCOTARGET 2016
            27043357 Human FREE RADICAL RESEARCH 2016
            25933112 Human PLOS ONE 2015
            24743737 Mouse CELL DEATH & DISEASE 2014
            24331664 Rat INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2014
            24211590 Mouse BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2013
            24012930 Human EUROPEAN JOURNAL OF PHARMACOLOGY 2013
            20371669 Human MOLECULAR PHARMACOLOGY 2010
            19139269 Human JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2009
                 
41 PP242 23 23 Mechanistic target of rapamycin kinase (MTOR) PDGFR, DNA-PK 26636543 Rat ONCOTARGET 2015
            28400912 Human OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
            27358039 Human SCIENTIFIC REPORTS 2016
            26643778 Mouse SCIENTIFIC REPORTS 2015
            23722550 Human CANCER RESEARCH 2013
                 
42 Rottlerin 23 37 Mechanistic target of rapamycin kinase (MTOR) Malate dehydrogenase 1 (MDH1) 28455500 Human SCIENTIFIC REPORTS 2017
            28101215 Human ONCOLOGY LETTERS 2016
            27626499 Human ONCOTARGET 2016
            27343979 Human CANCER LETTERS 2016
            25661734 Human CANCER LETTERS 2015
                 
43 Monensin 22 18 Lysosomal pH   15657430 Human MOLECULAR AND CELLULAR BIOLOGY 2005
            20083895 Human AUTOPHAGY 2010
            20544854 Rat GLIA 2010
            25181483 Mouse PLOS ONE 2014
            26293158 Rat JOURNAL OF LIPID RESEARCH 2015
                 
44 Spautin_1 20 20     21962518 Human CELL 2011
            24585095 Human INTERNATIONAL JOURNAL OF ONCOLOGY 2014
            25002530 Human MOLECULAR AND CELLULAR BIOLOGY 2014
            24562574 Human CARCINOGENESIS 2014
            26565512 Mouse AUTOPHAGY 2016
            27579473 Mouse, Rat MOLECULAR MEDICINE 2016
            27787915 Human MOLECULAR CARCINOGENESIS 2017
            28575052 Human PLOS ONE 2017
                 
45 Amiodarone 20 15 Mechanistic target of rapamycin kinase (MTOR) Thyroid hormone receptor, alpha (THRA), Thyroid hormone receptor beta (THRB), Peroxisome proliferator-activated receptor gamma (PPARG), adrenoceptor beta 1 (ADRB1). 26735341 Rat ONCOTARGET 2016
            26515640 Mouse JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2015
            26515640 Mouse SCIENTIFIC REPORTS 2015
            25957292 Mouse AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2015
            25881747 Human BIOCHEMICAL PHARMACOLOGY 2015
            23912912 Rat TOXICOLOGICAL SCIENCES 2013
            19771169 Mouse PLOS ONE 2009
                 
46 ConcanamycinA 18 22 Lysosomal pH Nuclear receptor subfamily 3 group C member 1 (NR3C1), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ), Nuclear receptor subfamily 4 group A member 3 (NR4A3) 26259639 Rat AUTOPHAGY 2015
            24174532 Human, Mouse JOURNAL OF BIOLOGICAL CHEMISTRY 2013
            23546223 Mouse INTERNATIONAL JOURNAL OF ONCOLOGY 2013
            9008702 Human JOURNAL OF CELL BIOLOGY 1997
            21289198 Human, Mouse JOURNAL OF NEUROSCIENCE 2011
            22311637 Human MOLECULAR & CELLULAR PROTEOMICS 2012
                 
47 Verapamil 17 16 Calcium channel potassium voltage-gated channel subfamily A member 1 (KCNA1), ATP binding cassette subfamily B member 1 (ABCB1) 23087153 Human PHARMACOLOGICAL REPORTS 2012
            25189398 Mouse NATURE COMMUNICATIONS 2014
            25484079 Human, Mouse AUTOPHAGY 2014
            26643325 Human ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2015
            28342290 Human FEBS JOURNAL 2017
                 
48 17_AAG 17 16     25957556 Rat NEUROSCIENCE LETTERS 2015
            25866220 Human NEOPLASMA 2015
            25196280 Human EXPERIMENTAL CELL RESEARCH 2014
            20959823 Rat BRITISH JOURNAL OF CANCER 2010
            20090920 Rat PLOS ONE 2010
                 
49 AZD8055 14 12 Mechanistic target of rapamycin kinase (MTOR) AKT serine/threonine kinase 1 (AKT1) 24297300 Human ONCOLOGY REPORTS 2014
            21949121 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2011
            27423593 Rat JOURNAL OF THE NEUROLOGICAL SCIENCES 2016
            24600487 Human INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 2014
            22143671 Mouse LEUKEMIA 2012
                 
50 Perifosine 12 19 Mechanistic target of rapamycin kinase (MTOR) AKT serine/threonine kinase 1 (AKT1) 25934232 Human BIOCHEMICAL PHARMACOLOGY 2015
            19920197 Mouse CANCER RESEARCH 2009
            25934232 Human BIOCHEMICAL PHARMACOLOGY 2015
            22407228 Human ACTA PHARMACOLOGICA SINICA 2012
            20371718 Mouse MOLECULAR CANCER THERAPEUTICS 2010
                 
51 Nigericin 11 9     27519418 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2016
            22493436 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2012
            26825654 Human EXPERIMENTAL CELL RESEARCH 2016
            24089192 Mouse JOURNAL OF IMMUNOLOGY 2013
            24312373 Mouse PLOS ONE 2013
                 
52 Troglitazone 11 10 Protein kinase AMP-activated (PRKA), Peroxisome proliferator activated receptor gamma (PPARG)   28460464 Human ONCOTARGET 2017
            24853624 Human CANCER GENE THERAPY 2014
            19923924 Human AUTOPHAGY 2010
            21871555 Human BIOTECHNOLOGY ADVANCES 2012
            19563910 Human INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2009
                 
53 Fenofibrate 10 11 Peroxisome proliferator activated receptor gamma (PPARG) Protein kinase AMP-activated (PRKA) 28422956 Mouse PLOS ONE 2017
            26795437 Mouse CLINICAL SCIENCE 2016
            25332241 Mouse MOLECULAR AND CELLULAR BIOLOGY 2015
            26795437 Mouse CLINICAL SCIENCE 2016
                 
54 Forskolin 8 6   Nuclear receptor subfamily 1 group D member 1 (NR1D1) 25951193 Human AUTOPHAGY 2015
            7657729 Human JOURNAL OF CELL SCIENCE 1995
                 
55 Niclosamide 8 8 Signal transducer and activator of transcription 3 (STAT3) Mechanistic target of rapamycin kinase (MTOR) 19771169 Mouse PLOS ONE 2009
            21203451 Human PLOS ONE 2010
            24174532 Human JOURNAL OF BIOLOGICAL CHEMISTRY 2013
            26784896 Human PLOS ONE 2016
            28627643 Rat MOLECULAR MEDICINE REPORTS 2017
                 
56 Apicidin 3 7 Histone deacetylases (HDAC) Coagulation factor VII (F7), Galanin receptor 2 (GALR2) 28178760 Human JOURNAL OF ORAL PATHOLOGY & MEDICINE 2017
            26539916 Human CELL DEATH & DISEASE 2015
            25647264 Human ONCOLOGY REPORTS 2015
            21983700 Human INVESTIGATIONAL NEW DRUGS 2012
            21856210 Human ORAL ONCOLOGY 2011
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