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  Literature about stucture and finction of nuclear receptors  
  Wurtz, J.M., Bourguet, W., Renaud, J.P., Vivat, V., Chambon, P., Moras, D., and Gronemeyer, H. (1996). A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 3, 87-94.

Robinson-Rechavi, M., Escriva Garcia, H., and Laudet, V. (2003). The nuclear receptor superfamily. J Cell Sci 116, 585-586.

Moras, D., and Gronemeyer, H. (1998). The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol 10, 384-391.

Markov, G.V., and Laudet, V. (2011). Origin and evolution of the ligand-binding ability of nuclear receptors. Mol Cell Endocrinol 334, 21-30.

Kojetin, D.J., and Burris, T.P. (2013). Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery. Mol Pharmacol 83, 1-8.

  Literature about therapeutic value of orphan nuclear receptors  

Benod, C., Vinogradova, M.V., Jouravel, N., Kim, G.E., Fletterick, R.J., and Sablin, E.P. (2011). Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A 108, 16927-16931.

Deutsch, A.J., Angerer, H., Fuchs, T.E., and Neumeister, P. (2012). The nuclear orphan receptors NR4A as therapeutic target in cancer therapy. Anticancer Agents Med Chem 12, 1001-1014.

Huang, Z., Xie, H., Wang, R., and Sun, Z. (2007). Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. Expert Opin Ther Targets 11, 737-743.

Kakizaki, S., Takizawa, D., Tojima, H., Horiguchi, N., Yamazaki, Y., and Mori, M. (2011). Nuclear receptors CAR and PXR; therapeutic targets for cholestatic liver disease. Front Biosci (Landmark Ed) 16, 2988-3005.

Khan, P.M., El-Gendy Bel, D., Kumar, N., Garcia-Ordonez, R., Lin, L., Ruiz, C.H., Cameron, M.D., Griffin, P.R., and Kamenecka, T.M. (2013). Small molecule amides as potent ROR-gamma selective modulators. Bioorg Med Chem Lett 23, 532-536.

Kim, M.K., Chanda, D., Lee, I.K., Choi, H.S., and Park, K.G. (2010). Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases. Expert Opin Ther Targets 14, 453-466.

Kojetin, D.J., and Burris, T.P. (2014).REV-ERB and ROR nuclear receptors as drug targets. Nat Rev Drug Discov 13, 197-216.

May, F.E. (2014). Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer. Cancer Manag Res 6, 225-252.

Nicolakakis, N., and Hamel, E. (2010). The Nuclear Receptor PPARgamma as a Therapeutic Target for Cerebrovascular and Brain Dysfunction in Alzheimer's Disease. Front Aging Neurosci 2.

Sherman, M.H., Downes, M., and Evans, R.M. (2012). Nuclear receptors as modulators of the tumor microenvironment. Cancer Prev Res (Phila) 5, 3-10.

Mandrekar-Colucci, S., and Landreth, G.E. (2011). Nuclear receptors as therapeutic targets for Alzheimer's disease. Expert Opin Ther Targets 15, 1085-1097.

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