Institute of Microbial Technology (सूक्ष्मजीव प्रौद्योगिकी संस्थान)
A Council of Scientific & Industrial Research (वैज्ञानिक औद्योगिक अनुसंधान परिषद)
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About Target

Various transcription factors and the cognate signaling molecules after sensing transmit the signal to the effectors which upregulate or downregulate the autophagic process. Yeast genetics has immensely widen our acquaintance with the molecular mechanisms of autophagy. About 30 autophagy related genes (ATGs) in yeast have been identified and homologues of these genes have been identified in mammals and they are largely conserved. The mammalian homolog of ATG6 is called Beclin1 (BECN1).

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About AutophagySMDB

AutophagySMDB (Autophagy Small Molecule Database) is an interactive, comprehensive manually curated database of small molecules and their protein targets which modulates autophagy. All small molecule entries includes 2D & 3D structure files along with information such as molecular formula, canonical smile, IUPAC name, function, PubMed ID, FDA approval status, quantitative structure activity relationship (QSAR) properties, experimental values such as Ki, Kd, IC50 and EC50 from published literature. This database can be searched by different options like text search, structure search and advanced search. We also implemented different advanced tools like clustering, cataloguing and tree functionality through which user can perform advanced structural analysis for drug discovery. All living organisms undergo continuous repair. Cells and other cellular components are invariably remodeled and recycled. This is, in part, in order to replace the unwanted old components with healthier ones. The term autophagy or “self-eating” signifies a well conserved catabolic process vital for cell viability and homeostasis. Since long it has been considered as a housekeeping pathway responsible for maintaining equilibrium between biosynthesis and intracellular degradation. Autophagy maneuvers major self-degradative mechanism by which a cell recycles its macromolecules and organelles thereby renovating the cells and tissues. Autophagy is a multistep process, subsequent to a stress signal first step is sequestration of damaged organelles, malformed proteins and other dysfunctional cellular components inside a membraned phagophore. Phagophore expands by surrounding a portion of cytoplasm into a double membraned autophagosome. Loaded autophagosome then fuses with.....

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About Small Molecule

In recent times, a range of small molecules have been discovered which can promote or inhibit the function of either signaling components or transcription factors which modulates autophagy. Generally, the "target" is the naturally existing cellular or molecular structure involved in the pathology of interest that the drug-in-development is destined to act on. Over the years, there have been small molecule information resources available like drug bank, KEGG DRUG Database, ONRLDB (Orphan nuclear receptor ligand database) which holds the small molecules or drugs information and their comprehensive targets. Autophagy has emerged as an important arm in various pathological conditions.

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